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Paralysis and the Stem Cell cure

Reference #: 604
Submit Date: 21 Jun 2004
Browse Category: paralysis
Author: none
Email Address: none
Treatment used: stem cells
You can buy this remedy at: china
Remedy will cost you: unknown
Country of Remedy: USA
Remedy Source: Knigtht Ridder Newspaper, Tim Johnson, June 9,2004
More Links about this Remedy: http://www.realcities.com/mld/krwashington/news/columnists/tim_johnson/8888651.htm
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Dosage Info:
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Dosages used in clinical trials are significant: unknown
Maximum dosages in relation to side effects and serious side effects: unknown
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Browse: paralysis

Remedy Description

Chinese doctor uses fetal cells to treat paralysis in controversial treatment



By Tim Johnson



Knight Ridder Newspapers, June 9, 2004



source:

http://www.realcities.com/mld/krwashington/news/columnists/tim_johnson/8888651.htm



BEIJING - Strolling briskly through the dim halls of Chaoyang Hospital,

neurosurgeon Huang Hongyun says his pioneering medical work using fetal

cells to treat paralysis and other nervous system ailments is swamping him

with attention.



The cell phone jangles. Lecture invitations mount. E-mails pour in from

around the world.



Huang is causing a stir in medical circles. Many U.S. scientists and

researchers have qualms about what he's doing. But hundreds of families of

paraplegics from the United States, Japan, Singapore and elsewhere are

lining up to bring loved ones to Beijing for an experimental operation that

may be able to help patients sit up by themselves. Or hold a cup. Or button

a shirt. Or sweat below their necks.



Huang is one of a handful of researchers around the world shattering the

centuries-old idea that paralysis is irreversible.



While the Bush administration sharply limits research into embryonic stem

cell and fetal tissue, citing moral and ethical considerations, nations

such as China are aggressively delving into such research.



Huang, a 48-year-old with an easy smile, is taking certain kinds of fetal

nerve cells, culturing them and transplanting them into patients with

spinal cord injuries or other nervous system disorders. In little more than

two years, he's done the operation nearly 450 times. More than 1,000 people

are on waiting lists.



"I was bowled over. They didn't have patients who were totally paralyzed

and then get up and walk. But there were people who couldn't hold objects,

and then they could after (the operation)," said Dr. Paul Cooper, a spinal

surgery expert at NYU School of Medicine.



The search for treatment for paralysis is at a high-profile juncture,

partly because of Christopher Reeve, the renowned actor who was paralyzed

after being thrown from a horse in 1995. As a quadriplegic, the strapping

portrayer of the titular character in the "Superman" movies has become a

forceful and blunt advocate for daring research.



Reeve blames a sluggish U.S. research establishment, lack of funding and

resistance from drug companies for failure to do more for spinal cord

injuries. Listening to Reeve, many of the 250,000 or so paraplegics in the

United States felt their anger catalyze over the medical view that little

can be done.



"My surgeons made it a point to come in my room, after about 30 days of

injury, to tell me I would never walk again. There was no encouragement. It

was just flat: You will never walk again," said Don Debolt, of Stewardson,

Ill., who came to Beijing to be operated on by Huang.



Debolt, who broke his neck when he rammed into a concrete wall at a water

park in Missouri in 1994, said any improvement would make a huge difference.



Debolt, 52, said he wants to move his legs at night, open a can of soda,

load a paper tray of a computer printer, "things most people take for granted."



Word of Huang's procedure has spread through the Internet, giving hope to

paraplegics and those with other nervous system disorders, such as

amyotrophic lateral sclerosis (ALS), a muscle-wasting disease. So far,

Huang has operated on 28 non-Chinese patients.



"I get hundreds and hundreds of people ask me, `Should I go to Beijing

now?' I say they should wait. But there is desperation. When you are a

quadriplegic, a year is an eternity," said Dr. Wise Young, a neuroscientist

at Rutgers University in New Jersey who's visited China repeatedly and

observed Huang's work.



Even so, Young said in a telephone interview, Huang's technique is unusual,

apparently not harmful and brings "modest" improvement in motor and sensory

functions.



"There's no one else in the world doing this," Young said.



Huang extracts certain cells, called olfactory ensheathing glial (OEG)

cells, from fetuses aborted during the second trimester of pregnancy.



The OEG cells, found above the bridge of the nose at the base of the brain,

are the only nerve cells in the body that regenerate throughout life. Fetal

OEG cells are more potent than those taken from adults.



Huang and his team grow more fetal OEG cells in a culture, then transplant

about a million of them slightly above and below the injured part of the

spine. Two or three days after the operation, many paralyzed patients

regain some sensation and movement.



"It's very hard to explain. It's too fast, too quick (for nerve

regeneration)," Huang said. "There is some mechanism. ... I don't know why

it works. (But) it helps patients."



In Portugal and Australia, researchers are also testing use of OEG cells on

spinal-cord patients, reporting positive results. Researchers in both

countries are extracting OEG cells from the patient, culturing them and

transplanting them back, rather than using aborted fetuses.



Some U.S. spinal cord experts, including critics and supporters of Huang's

work, are troubled that he's plunged into widespread clinical use. They

urge trials.



Dr. Barth A. Green, one of the leading U.S. spinal cord injury experts,

said desperation sometimes leads U.S. patients to "discard good medical

advice and common sense" in looking for treatment abroad.



"They often fly off in the wild blue yonder seeking care and a cure," said

Green, the president of The Miami Project to Cure Paralysis, a spinal-cord

injury research center. He noted that the actor Steve McQueen flew to

Mexico in 1980 for a dose of apricot pits before succumbing to cancer.



Huang's patients dispute that they're acting rashly, saying they've

benefited from the surgery, which costs $20,000 for foreigners and about

$6,000 for Chinese.



"Before, I had no sensation in my arms from my armpits down. I now have

sensation in both arms down to my hands," said Leo Per Hallan, a South

Dakota man who underwent the experimental surgery in Beijing in April.



Huang said a few paraplegics have recovered limited sexual function.



His team has also treated dozens of patients suffering from ALS, multiple

sclerosis and other nervous system ailments by transplanting OEG cells

through holes in the skull.



"My husband's tremors ceased the day after surgery. He could shave by

himself. He was ecstatic," said Toni Shoham, of Granby, Conn., whose

76-year-old husband, Robert, underwent treatment for ALS in Beijing about a

month ago. "My husband could barely talk, swallow or drink. Now he can do

all of that."



The use of fetal tissue troubles some of the patients - to a degree.



"I'm strongly anti-abortion," Debolt said. "But I'm also of the belief that

my being here doesn't cause the abortion. The abortion is going to occur

independent of whether I use the cells or not. I equate this with organ

donation."



Huang, who did post-graduate work at Rutgers in the late 1990s, looked a

little puzzled at a query about the ethics of fetal tissue use, a

widespread practice in China, saying he saw no problem with it.



Chinese government support for novel medical research is growing quickly,

especially in stem cells, a largely unregulated field.



Some of the findings haven't been published in respected scientific

journals because researchers - like Huang and his team - haven't conducted

rigorous clinical trials with scientific controls.



Until such trials are done, doubt may enshroud Huang's procedure, even as

advances are reported elsewhere, such as The Miami Project's recent

discovery that insulating cells from the peripheral nervous system might

help spinal cord injury.



Huang, who said he hopes to work with The Miami Project to design clinical

trials, perhaps later this year, beamed as he showed videos of some of his

patients from before and after their surgeries.



"Look, now he can hold the cup," he said, showing video of a Chinese

quadriplegic grasping a teacup and drinking.



Another patient, a 41-year-old quadriplegic, can be seen slowly writing

Chinese characters.



Said Huang: "This is the first time after many years that he is writing."



---



(c) 2004, Knight Ridder/Tribune Information Services

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